Hyaluronidase Injection as an Adjuvant

Hyaluronidase Injection is a medication that requires a prescription and is used to help other drugs absorb better when given through the skin. One of its use-cases is to improve the absorption of radioactive substances and fluids or medications injected into the skin in subcutaneous urography. However, Hyaluronidase Injection should only be given by a doctor or under their direct supervision.

What Is Hyalurodinase Injection?

Hyaluronidase Injection is a pharmaceutical substance combined with other medications and injected under the skin to enhance their absorption by the body. Hyaluronidase is a genetically designed protein found in the body or obtained from cows or pigs. It can be purified to remove animal components or synthesized in a laboratory using human albumin sources. Hyaluronidase Injection is a type of medication that falls under the endoglycosidase category.

Uses of Hyalurodinase Injection

• Absorption and Dispersion of Injected Drugs

 Hyaluronidase Injection helps other drugs to be absorbed and distributed better.

• Hypodermoclysis

Hyaluronidase Injection is recommended to help with hydration when administering fluids under the skin.

• Subcutaneous Urography

Hyaluronidase Injection can improve the absorption of radiopaque substances in subcutaneous urography as an additional treatment.

Benefits of Using Hyalurodinase Injection

• In Preservative

Hyalurodinase injection aims to protect injectable medications from being damaged by harmful organisms. Without it, these organisms can contaminate the drug and cause adverse reactions or infections in the patient.

How Does This Medication Work?

Hyaluronidase Injection breaks down hyaluronic acid by terminating the bond between glucuronic acid, an integral part of the extracellular matrix. Hyaluronidase injection with other substances helps them permeate the extracellular space more efficiently.

The Hyaluronidase Injection begins to work immediately, within 24 hours, depending on the amount injected and the treatment goals. In some cases, results may be visible shortly after injection, and the treatment continues to work over time.

Directions for Using Hyaluronidase Injection

Before starting the treatment, read the information leaflet provided by the manufacturer on the container. Let your healthcare provider know if you have had any unusual or adverse reactions to this or other medications. Also, inform your doctor if you have allergies to food, preservatives, or animals.

Before administering parenteral drug products, it is essential to visually check for any particles or discoloration if the container and solution allow for it.

You can administer Hyaluronidase Injection with or without food.

Taking medicine daily or as prescribed by your physician is recommended for optimal results. Employing a calendar reminder can help you maintain the desired schedule.

Note: If you forget to take your medication, take it as soon as you recall. If it's almost time for your next dose, ignore the missed one and take the next one as planned. Do not take additional medication to compensate for the missed dose.

Hyaluronidase Injection Dosage Forms

Follow the instructions provided in the medication guide. Do not exceed the recommended dosage or frequency; only take medicine for the duration your doctor prescribes. Contact your physician if you have any questions. Hyaluronidase Injection is administered through different methods such as infiltration, interstitial, intramuscular, intraocular, retro bulbar, soft tissue, and subcutaneous.

• Absorption and Dispersion of Subcutaneously Injected Drugs

Adults: Normally, the injection solution has 50 to 300 Units added to it, as well as 150 Units of Hyaluronidase.

Children: The doctor must provide directives as to the ideal dosage to be used.

• In the Treatment of Hypodermoclysis

Adults: The doctor must figure out the correct way and dosage of medication to be used.

Children: The doctor must guide you on the correct mode and dosage of medication to be used.

• For Subcutaneous Urography

Adults: Your physician must decide the correct way and dosage to use medicine.

Children: Administer 75 Units of Hyaluronidase Injection under the skin on each shoulder blade, and then inject the contrast medium at the exact locations.

Storage

• Keep drugs out of the reach and sight of children.
• Store the vials between 2° - 8°C (36° and 46°F). Protect from light and moisture.
• Do not freeze.

Unless instructed differently, please do not dispose of Hyaluronidase Injections by flushing them down the toilet.

Possible Side Effects of Hyaluronidase Injection

Most pharmaceutical drugs can result in adverse effects, known as side effects, pointing to unintended reactions to the medication at the appropriate dosage. These consequences can range from mild to severe and can be temporary or long-lasting. The following are some of the adverse effects of Hyaluronidase Injection:

Most Common Side Effects

• Acute Urticaria
• Anaphylactic reaction
• Angioedema
• Hormone imbalance
• Injection site reactions (pain, swelling, redness, coldness)

Less Common Side Effects

• Blurred vision
• Chills
• Confusion
• Cough
• Sweating
• Swelling

Note: If you have any strange side effects, like muscle spasms, heart rhythm disturbances, seizures, a rash on your nose and cheeks, or worsening joint pain, it is vital to notify your doctor right away.

Warnings and Precautions

Before taking Hyaluronidase Injection, it is crucial to inform your healthcare provider or pharmacist about any allergies you may have. The inactive ingredients in the product may lead to allergic reactions or other issues. Your clinician can provide you with more information.

Following the recommended medication and completing the treatment is essential, even if you start feeling well. Stopping may cause the infection to return and be harder to treat.

Before administering Hyaluronidase Injection, your doctor may conduct a skin test to determine if you are allergic to it.

It is vital to take aseptic measures when utilizing this therapy.

If you experience a rash, hives, redness, itching, or difficulty breathing after receiving Hyaluronidase, inform your doctor.

Injecting Hyaluronidase in or near an infected or inflamed area can spread the infection, so avoid it.

Before altering the dosage or discontinuing medication, seeking advice from a physician is crucial.

This medication is made from human blood donations, but there’s a negligible risk of transmitting viruses to patients who receive it. Donors and donated blood are both screened for viruses to minimize this risk. If you have concerns, you should talk to your doctor.

Drug Interactions and Contraindications

It is essential to inform your healthcare provider if you are taking any of the medications listed below, as combining them with this injection is not recommended. Your doctor may opt to alter your current medications or not prescribe this drug at all. The following medications interact with Hyalurodinase Injection:

• Amiloride hydrochloride dihydrate
• Brimonidine tartrate
• Bromocriptine
• Phenytoin
• Prilocaine
• Ropinirole hydrochloride

Individuals with severe allergies, Liver and kidney disease should avoid this therapy.

Alternatives Hyaluronidase Injection

• Dexrazoxane Injection 250mg
• Facidase 1500IU Injection
• Hylorase 1500IU Injection

Buying Hyaluronidase Injection from a Trusted Online Store

Kiwi Drug offers affordable access to all medications to people on all continents. Subject to industry regulations, Kiwi uses professional pharmacists to ensure that clients receive the best services and maintain the optimum quality of life. You require a prescription for Hyaluronidase Injection. At Kiwi Drug Store, a certified online doctor will review your medical profile and write you a prescription through the online doctor service, which you can use to buy the drug. Thus, purchasing Hyaluronidase Injection from Kiwi Drug is straightforward and quick, with or without a prescription. It involves:

• Signing up and adding the drug to the cart
• Clicking the "Checkout Now" button
• Answering the questions presented on the next page
• Entering payment details and waiting for your order to arrive