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Evorel Conti Patch (estradiol, norethisterone) is used in Hormone Replacement Therapy (HRT), most commonly in women who are experiencing symptoms of menopause. It is also used to help prevent osteoporosis in post-menopausal women, and less commonly in other conditions.

Evorel Conti Patch is a continuous combined HRT, which means it contains both an estrogen hormone, estradiol, and a progestogen hormone, norethisterone. In women who have a uterus it is important that estrogen therapy include a progestogen to reduce risk of developing certain types of cancer, as well as other complications. Women who have had a hysterectomy do not need to worry about taking a progestogen and will find estrogen-only treatments, such as Evorel patches, more suitable.

This product is available in packs of 8 or 24 patches, both of which are identical in dosage strength.

HRT with Evorel Conti Patch

As mentioned above, this product is most frequently used in women experiencing disruptive symptoms associated with low estrogen levels, including:

• Hot flashes and night sweats
• Digestive problems
• Difficulty falling or staying asleep
• Moodiness
• Vaginal dryness
• Dry, brittle, and/or thinning hair, nails, and skin
• Loss of libido
• Headaches

It takes a few weeks of treatment for full effects to be felt. Dosage adjustments are not unusual over the course of treatment. In the majority of cases HRT is meant to help the body adjust to menopause gradually, but not to maintain HRT indefinitely; it does carry risk of adverse effects---some of which can be quite serious---and these risks increase with duration of use. The risks versus benefits of HRT should be reevaluated at least once per year.

Evorel Conti Patch does see application in other scenarios, for example:

• Certain ovarian disorders
• Abnormal vaginal bleeding
• Post-menopausal osteoporosis
• Certain types of cancer

The hormone estrogen sees much wider use, such as treating certain types of cancer in men or promoting female characteristics in gender transitions, but, since the progestogen included in Evorel Conti Patch provides no benefit to individuals without a uterus, estrogen-only treatments are preferred in these cases.

Warnings & Side Effects

Some individuals are at increased risk of experiencing potentially serious complications while using Evorel Conti Patch. Do not use this or any other estrogen supplement without explicit doctor instruction if there is a history of:

• Breast cancer, including family history
• Blood clots
• Liver impairment
• Hypertension (high blood pressure)
• Diabetes
• Migraines
• Epilepsy
• Any heart problems
• Any circulation problems

The above conditions do not necessarily mean an estrogen supplement cannot be used, but risks should be carefully discussed with a doctor beforehand. Likewise routine checkups should be performed to monitor for any developing complications.

In otherwise healthy patients side effects are rare, usually mild, and should fade away as the body adjusts to treatment. The most commonly reported side effects include:

• Lightheadedness
• Headache
• Breast tenderness
• Mood swings
• Increased blood pressure
• Libido changes
• Vaginal thrush
• Fluid retention (edema)
• Abdominal upset

The above side effects are generally not cause for concern unless severe or persistent. Speak with a doctor if concerned; a dosage adjustment may help.

Other medications can interfere with the effectiveness of Evorel Conti Patch, most notably:

• Bosentan
• Rifampicin
• Rifabutin
• Telaprevir
• Nevirapine
• Efavirenz
• Ritonavir
• Nelfinavir
• Phenobarbital
• Carbamazepine
• Phenytoin
• St. John’s Wort

The above is not a complete list of medications that may interact with Evorel Conti Patch. Check with a doctor or pharmacist before mixing medications.