Indivina

Indivina is a hormonal pill for treating postmenopausal symptoms and preventing osteoporosis in women above 50. The drug reduces the risk of fractures in women with deficient female hormones leading to fragile bones. However, the long-term risks of using Indivina to prevent osteoporosis sometimes outweigh the benefits. The doctor will only prescribe this medication if you cannot tolerate other drugs for osteoporosis.  

What is Indivina?

Indivina is a form of hormonal replacement therapy (HRT) that contain two active ingredients; estradiol and medroxyprogesterone. These are forms of female sex hormones, with estradiol being a naturally occurring variant of estrogen, while medroxyprogesterone is a synthetic version of progesterone.

What is Indivina Used for, and How Does it Work?

Postmenopausal symptoms

As women approach menopause, the ovarian production of estrogen decreases with a subsequent decline in estrogen blood levels. The drop causes unpleasant symptoms such as hot flashes and night sweats, irregular bleeds, disturbed sleep, mood swings, vaginal dryness or itching, and headaches.

Supplementing the falling estrogen levels through hormonal replacement therapy helps to reverse these distressing symptoms associated with menopause. Indivina contains estradiol, a form of estrogen that boosts blood levels and relieves postmenopausal symptoms.

Naturally, estrogen stimulates the growth of the endometrium (inner lining of the uterus). When given alone in HRT treatment, it causes excessive endometrial growth that can lead to cancer. Therefore, progesterone (in this case, medroxyprogesterone) is included as part of the hormonal replacement therapy to counter the impact of estrogen on the womb lining and reduce the risk of cancer. Since Indivina contains versions of estrogen and progesterone, it is known as combined HRT and should only be used by women at least three years past menopause. Those taking this hormonal tablet do not experience monthly menstrual bleeding.

Note: HRT is recommended on a short-term basis with a mandatory doctor's review within a year.

Prevent osteoporosis in postmenopausal women

Estrogen hormone is crucial in maintaining bone density. As women approach menopause, ovarian production of estrogen decrease and, the estrogen blood levels decline, bones become thinner and vulnerable to fractures, a condition known as osteoporosis. Hormonal replacement therapy using Indivina helps to prevent bone loss and reduce the risk of fractures that often occur after menopause. That said, long-term use of Indivina for preventing osteoporosis has more potential risks than benefits. Thus, this tablet is only prescribed as a second-line treatment for those who cannot tolerate the first-choice osteoporosis medications such as alendronate.

How to Use Indivina Tablets

Only women past menopause (at least three years after the last monthly menstrual bleed) should take this medication. Read the patient information leaflet that comes with the pack carefully before using the Indivina tablets. Take the drug exactly as directed by the doctor.

Indivina is a continuous HRT tablet and should be taken once daily for the prescribed period without a break. Swallow the pill whole with water or juice. You can take the medication with or without food.

Each tablet on the pack is marked with a day of the week to help you remember when to take them. Try to take the pills at the same time of the day but if you miss a dose, skip the missed dose and continue with the usual schedule. Do not take two tablets in the next dose to compensate for the missed one.

Some women experience irregular bleeding during the first few months of therapy. This is normal but if the bleeding does not resolve within three months of treatment, speak to the doctor for advice.

HRT is only recommended for those whose postmenopausal symptoms affect their quality of life. Use Indivina for the shortest time and the lowest dose possible to relieve the distressing symptoms.

Speak to the doctor about any dosage concerns or side effects that arise during therapy.

The doctor should review your need for continuous HRT at least once a year. Be sure to book an appointment with the provider for a gynecological review every year, as long as you take the pills.

Form and Dosage

Indivina is available as 1/2.5 mg, 1/5 mg, and 2/5 mg tablets. The recommended initial daily dose is 1/2.5 mg tablet, equivalent to 1 mg of estradiol and 2.5 mg of medroxyprogesterone. Dose adjustment is made depending on the clinical response. For instance, if breakthrough bleeding persists when using the 1/ 2.5 mg tablet, the doctor can switch to 1/5mg tablet once an endometrial abnormality is ruled out. If the doctor prescribes a different dose from the stated, follow the doctor's instructions.

Possible Side Effects of Indivina

All medications, including HRT tablets, can have side effects. Those taking Indivina might experience unwanted responses despite using the drug in the recommended dosage and frequency. The side effects usually vary from person to person, but not everyone using the combined HRT experience these undesired effects. Contact the doctor if any bothersome symptom occurs when taking Indivina pills.

Potential Indivina side effects include:

• breast pain or enlargement
• stomach cramps and gas
• nausea and vomiting
• headache
• menstrual spitting
• leg or body swelling due to fluid retention
• dizziness
• weight changes
• altered sexual drive
• mood swings with anxiety, depression, and irritability
• skin reactions, including rash and itching
• leg cramps
• premenstrual symptoms such as abdominal cramps and mood changes
• enlarging of uterine fibroids
• difficulty wearing contact lenses due to corneal curvature changes
• elevated blood pressure

Some Indivina side effects are severe; if they occur, contact the doctor immediately. They include;

• Hypersensitivity reaction, characterized by difficulty breathing, swelling of the face or throat, and hives
• Liver disease, causing yellowing of the eyes or skin
• Blood clot with signs of stroke or pulmonary embolism

Indivina users might experience side effects besides those listed here or on the medication leaflet. Consult the healthcare provider if any unusual symptom occurs when taking the hormonal pill.

Precautions and Warnings

• Inform the doctor of any significant medical history, including liver disease, diabetes, and endometriosis, before starting Indivina therapy.
• Indivina use is associated with a slightly increased risk of breast and endometrial cancer. Women with a suspected or known family history of such cancers should not take these HRT tablets.
• Indivina is not a contraceptive and should only be taken by postmenopausal women. Those under 50 or who had their last normal menstrual bleed within the previous year should consider contraception while taking Indivina. Do not take this medicine when pregnant or breastfeeding.
• Those at risk of developing blood clots or with a history of vascular diseases such as stroke, heart attack, or pulmonary embolism should not use Indivina.

Drug Interactions

Before starting Indivina therapy, inform the doctor of your medications, including prescribed, over-the-counter, and herbal products. This will help prevent adverse effects that might result from the interaction between Indivina and the other medications.

Drugs that can interact with Indivina include;

• Aprepitant
• Phenytoin
• Insulin for diabetes
• Fluid retention medications like furosemide
• Barbiturates
• St John's wort in herbal medicines
• Selegiline

Confirm with the doctor if any drug combination with Indivina is safe before taking it.

Contraindications

• Allergy to Indivina ingredients
• Suspected, known or past history of breast cancer and other estrogen-dependent tumors
• Genital bleeding of unknown cause
• Untreated endometrial hyperplasia
• Blood clotting disorder

Alternatives to Indivina

• Tridestra
• Evorel
• Elleste Duet
• Femoston
• Gina

Buying Indivina Online

Kiwi Drug offers affordable access to all medications to people on all continents. Subject to industry regulations, Kiwi uses professional pharmacists to ensure the clients receive the best services and maintain optimum quality of life. You need a prescription to buy Indivina. Kiwi Drug's online doctor service allows a doctor to review your medical profile and prescribe the medication. However, the process is even more straightforward if you have a prescription from your provider. To purchase the medicine, follow the steps below:

• Sign up and add Indivina to the cart
• Click the "Checkout Now" button
• Answer the questions presented on the next page
• Enter payment details and wait for your order to arrive