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Zofran (ondansetron) is an antiemetic medication used to prevent nausea and vomiting in patients undergoing radiation therapy or chemotherapy. It can also be used in a range of other scenarios which involve nausea, though the medication has little effect on motion sickness.

This product is available as injections, tablets, orally-disintegrating tablets, and oral solution. It is largely a matter of personal preference which one is used. The medication can be used in patients as young as 4, though dosage adjustments are required.

Use & Administration of Zofran

Zofran is an effective medication, alleviating nausea and vomiting in a range of conditions:

• Radiation or chemotherapy
• Postoperative nausea
• Gastroenteritis
• Morning sickness
• Hyperemesis gravidarum
• Cyclic vomiting syndrome

As tablets and orally-dissolving tablets, the medication is only available in two strengths; 4 mg and 8 mg. The 4-mg version is typically reserved for children under 12 years of age. Dosage for those 12 and up ranges from 8 to 24 mg, depending on the condition being treated; 24 is generally given for chemotherapy, while other conditions take 8 to 16 mg. Patients with severe hepatic impairment should not take more than 8 mg in a day.

Zofran is usually administered before the procedure that induces nausea; before chemotherapy, radiation therapy, anesthesia, etc. Doses may continue after the procedure as well, sometimes in smaller doses, typically for 1 or 2 days. The exception here is in pregnancy and cyclic vomiting syndrome, when one might not be able to predict vomiting. In cyclic vomiting syndrome Zofran is effective in mild to moderate cases; it has little effect on severe cases.

There is some evidence that Zofran improves symptoms of schizophrenia, as well as the repetitive motions associated with antipsychotic use. This is an off-label, largely experimental use and it's difficult to find dosage and duration of use guidelines.

Warnings before Use

Zofran is well-tolerated, with common side effects being very mild. They include:

• Headache
• Dizziness
• Constipation
• Diarrhea
• Weakness
• Fever
• Drowsiness

Rarely more serious side effects are experienced, which call for medical attention. These are more likely at higher doses. Call a doctor if experiencing:

• Blurred vision
• Vision loss
• Slow, rapid or pounding heartbeat
• Decrease in urine
• Feeling like or passing out
• Difficulty breathing
• Shivering or tremor

Zofran is associated with prolonged QT intervals, again particularly at higher doses. It is also more likely in patients with a history, including family history, of prolonged QT intervals, or in patients taking medications that prolong QT intervals. Be sure the prescribing physician knows of any history of prolonged QT intervals.

Zofran can interact with a range of other medications, most notably:

• Antibiotics
• Antidepressants
• Anti-malarials
• Antipsychotics
• Narcotics
• Seizure medications
• Migraine medications
• Other anti-nausea medications

The above is not a complete list of medications that can interact with Zofran. While not all interactions are dangerous, they may decrease the effectiveness of one or more medications involved. Speak with a doctor or pharmacist if unsure of the safety of taking other medications with Zofran.

Zofran can be used while pregnant, but should not be used while breastfeeding. Mothers suffering from severe morning sickness or hyperemesis gravidarum should speak with a doctor before taking Zofran.

Zofran Injection for Nausea and Vomiting

Zofran Injection is a prescription drug primarily used to alleviate nausea and vomiting induced by surgery or cancer treatment (chemotherapy). This medication inhibits the effects of substances in the body that cause nausea and vomiting. It may be offered under brand names or in several forms.

What Is Zofran Injection?

Zofran Injection contains the active ingredient hydrochloride dihydrate, which lowers the effects of serotonin, a naturally occurring neurotransmitter in the body that induces nausea and vomiting.

This medication is of the antiemetics medicine class.

How Does Zofran Injection Work?

In the vagal nerve, it blocks the effect of serotonin at 5HT3 – receptor sites (selective antagonist). The chemoreceptors trigger the central nervous system, decreasing the severity of nausea and vomiting following chemotherapy or surgery.

The action of this medicine is visible 15-30 minutes after oral administration and lasts for an average of 4 -8 hours.

Uses of Zofran Injection

Zofran Injection is used to treat nausea and vomiting induced by cancer treatments (chemotherapy or radiation), such as high-dose cisplatin. This medication also prevents and helps manage sickness and vomiting following surgery.

Benefits of Zofran Injection

Zofran Injection is a powerful medication that works by inhibiting the function of substances in the body that cause nausea and vomiting. This injection can significantly enhance the quality of life while preventing serious health consequences.

How to Use Zofran Injection

Before commencing the therapy, read the manufacturer's printed information page contained within the package. Inform your healthcare provider if you have ever experienced an unusual or adverse reaction to this or any other medications. Also, notify your physician if you have noteworthy allergies, such as foods, preservatives, or animals.

Use Zofran Injection to limit chemotherapy-induced nausea and vomiting before or within two hours after surgery.

Through an IV, a clinician injects this medicine into a vein. A healthcare practitioner must administer this injection.

Your clinician can administer a second and third dosage. That said, this must be 4 and 8 hours respectively following your initial dose.

If your clinician advices you to use this medicine regularly, be sure to take it on time. It’s recommended that you use it at the exact times every day to help you remember.

Learn all preparation and administration instructions from your healthcare practitioner if you administer this medicine at home. Examine the vial and the vial lid for particulates. If there are particles present, shake the bottle to re-dissolve them. Do not use the liquid if any particles remain after shaking the container.

Do not dispose of this medication in wastewater (e.g., down the sink or toilet) or in household garbage. Discuss with your doctor about proper disposal of drugs that are no longer needed or have expired.

If you forget to take a dosage, take it as soon as possible and resume your usual routine. If the time for your next session is near, omit the missing dose and maintain your standard dosing regimen.

Note: Do not duplicate the dose to make up for a missing one. If you are still trying to figure out what to do after missing a dosage, seek guidance from your clinician or pharmacist.

Zofran Injection Dosage Forms

Zofran Injection is a clear, colorless, nonpyrogenic, sterile solution for intravenous administration. This medication is only accessible with a doctor's prescription.

To be administered intravenously (IV):

• Adults: Inject 0.15mg/Kg 15-30 minutes before chemotherapy. Repeat after 4-8 hours for subsequent doses up to 16mg per dose.
• Children (6-18 years): 15-30 minutes before chemotherapy, inject 0.15mg/kg. Repeat every 4-8 hours for additional doses up to 16mg per dosage.
• Children (1 month – 12 years): Inject 4mg (> 40 kg); 0.1mg/Kg (≤ 40 kg).

Storage

• Keep drugs out of the reach and sight of children.
• Store the vials between 2° and 30°C (36° and 86°F). Protect from light and moisture.

Possible Side Effects

Many drugs might have adverse effects. A side effect is an undesired reaction to a medicine when taken at the recommended dose. Undesirable consequences might be moderate or severe, and they can be transitory or permanent. The following are some of the adverse effects of Zofran Injection.

Serious Side Effects

• A light-headed sensation
• Constipation
• Drowsiness
• Hallucinations
• Redness at the injection site
• Minimal or no urinating
• Tiredness
• Vision distortion

Common Side Effects

• Low Blood Pressure
• Hiccups
• Headache
• Unexpected exhaustion or weakness
• Warmth sensation

Rare Side Effects

• Dizziness
• Dryness of the mouth
• Chilly
• Hypotension
• Immediate hypersensitivity reactions
• Itching
• Pain, discomfort, or tightness in the chest

Note: Contact your doctor if any of the above side effects are severe or troublesome. Your physician can guide you on how to cope with adverse reactions.

Precautions and Warnings

Do not take this medication if you are allergic to Zofran Injection. Inactive ingredients in this product may cause adverse reactions. Consult your doctor before taking the medication.

If you or your kid is taking Apomorphine Apokyn, do not take this medication. When taken together, they can have considerable adverse effects.

Do not use Zofran Injection if you have anxiety, restlessness issues, a rapid heartbeat, fever, sweating, muscular spasms, twitching, nausea, vomiting, diarrhea, or hallucination concerns.

Avoid prescription and nonprescription (over-the-counter [OTC]) medications and herbal plus vitamin supplements unless recommended by your doctor.

Patients who exhibit indications of subacute intestinal blockage after receiving this injection should use the drug cautiously.

This medication should be avoided by those over 65, pregnant women, and nursing mothers. Depending on your clinical situation, your physician may recommend a safer choice with the same therapeutic effect.

If you have a liver illness or impaired liver function, talk to your doctor to see whether you need extra monitoring.

Avoid combining Zofran Injection with solutions not tested for physical and chemical compatibility.

If you administer this drug quicker than suggested or take more than the prescribed amount, you may experience significant adverse effects such as clouded vision or slowed/irregular heartbeat.

Drug Interactions

Let your healthcare practitioner know if you are taking any medications mentioned below when you receive this drug. Taking this injection with any of the following treatments is not recommended. Your doctor may opt for an alternative prescription or may adjust some of the medications you are already taking.

The following medications interact with Zofran Injection:

Interaction With Medicine

• Abiraterone acetate
• Acetazolamide
• Dronedarone
• Erythromycin
• Ketoconazole
• Phenytoin
• Posaconazole
• Pyrazinamide

Disease Interaction

• Bowel blockage diseases
• Electrolyte imbalance
• Gastric distension
• Heart rhythm problems
• Severe Liver disease

Contraindications

Do not use Zofran Injection on individuals struggling with:

• Hypersensitivity (anaphylaxis)
• Phenylketonuria
• Congenital long QT syndrome
• Concurrent use of apomorphine

Alternative to Zofran Injection

• Metoclopramide 10mg
• Promethazine 25mg
• Methylprednisolone 40mg/1ml

Buying Zofran Injection from a Trusted Online Store

Kiwi Drug offers affordable access to all medications to people on all continents. Subject to industry regulations, Kiwi uses professional pharmacists to ensure the clients receive the best services and maintain optimum quality of life.

You require a prescription to purchase Zofran Injection. But this doesn’t mean you must come with a prescription from your doctor’s clinic. At Kiwi Drug store, a certified online doctor will review your medical profile and write you a prescription through the online doctor service, which you can use to buy the drug. Thus, purchasing Zofran Injection from Kiwi Drug, with or without a prescription, is straightforward and quick. It involves:

• Signing up and adding the drug to the cart
• Clicking the “Checkout Now” button
• Answering the questions presented on the next page
• Entering payment details and waiting for your order to arrive