Kliovance

Overall Description

Kliovance is a type of medicine used majorly as a hormone replacement therapy (HRT). Its main function is to relieve menopausal symptoms in women, particularly those who’ve never had their uterus removed. Kliovance is also effective in preventing the risk of fractures in postmenopausal women.

Kliovance comes in the form of tablets. Each tablet has two active ingredients; norethisterone acetate and estradiol hemihydrate. Basically, these ingredients are part of the main female sex hormones, progesterone, and estrogen. Norethisterone is a type of synthetic progesterone while estradiol is a form of naturally occurring estrogen. 

As women age their levels of estrogen decline, causing distressing symptoms like hot flashes, irregular periods, mood swings, night sweats, and vaginal itching or dryness. To prevent such cases, doctors or pharmacists recommend Kliovance for women starting their menopause.

Benefits of Kliovance

Kliovance is useful in the following ways:

1. Provides an alternative treatment to prevent cases such as osteoporosis in most women who’ve gone through menopause.

2. Short-term treatment of most menopause symptoms like night sweats and hot flashes among those women without hysterectomy.

Side Effects

Possible Side Effects

Just like all medicines, Kliovance has side effects. But the side effects don’t affect everyone who takes this medication. Here are reported diseases that are more prevalent with women using Hormone Replacement Therapy (HRT) compared to those who don’t:

• Stroke

• Breast cancer

• Ovarian cancer

• Heat disease

• Endometrial hyperplasia cancer or abnormal growth on the lining of the womb

• Blood clots, especially in the veins of the lungs or legs

• Loss of memory for women aged more than 65 and on HRT

Uncommon Side Effects-Hypersensitivity/Allergy

This side effect affects 1 to 10 people in 1000 users. Its signs include one or several of these symptoms:

• Itching

• Hives

• Swelling

• Feeling dizzy

• Sweating

• Difficulty in breathing

• Low blood pressure, which may lead to cold on the skin, paleness, and rapid heartbeat

Very common Side Effects

Very common side effects of Kliovance affect 1 out of 10. Some of these effects include:

• Breast tenderness 

• Breast pain

• Vaginal bleeding

Common Side Effects

• Nausea

• Headache

• Weight gain due to fluid retention

• Vaginal inflammation

• Vaginal infection (fungal)

• Depression

• Uterine fibroid or benign tumor

• Breast edema (swelling or enlargement of the breasts) 

Uncommon Side Effects

Uncommon Side Effects affect between 1 and 10 people in 1000. These effects are as follows:

• Acne

• Bloating

• Abdominal pain

• Discomfort or flatulence

• Hair loss

• Abnormal hair growth among men

• Urticaria  itching or hives

• Leg cramps

• Inflammation of veins  also known as superficial thrombophlebitis

• Nervousness

• Allergic reaction

• Drug ineffective

If any of the symptoms above appear, the patient should stop taking Kliovance immediately and seek medical help from a reputed health professional.

Popular Interactions with Other Drugs or Conditions

It is advisable for the patient to discuss with her doctor or pharmacist the type of medicines she is already taking before the commencement of treatment. These medicines should include those obtained without a prescription. Not to mention herbal medicines. Likewise, the patient needs to confirm with her physician before taking any other medication while using Kliovance to ensure that the combination is absolutely safe. 

Below are examples of medicines that may lower the blood levels and effectiveness of Kliovance:

• Aprepitant

• Bosentan

• Barbiturates

• Eslicarbazepine

• Carbamazepine

• Fosaprepitant

• Modafinil

• Phenobarbital

• Rifabutin

• Crizotinib

• phenytoin

• Fosphenytoin

• Oxcarbazepine

• Vemurafenib

• Cobicistat

• Primidone

• Telaprevir

• Dabrafenib

• the herbal remedy St John's wort (Hypericum perforatum)

Also, Kliovance is likely to increase blood pressure levels when taken alongside these medicines and the risk of their side effects:

• Aminophylline

• Selegiline

• Ropinirole

• Tizanidine

• Theophylline

Additional medicines that contain almost similar active ingredients are:

• Climagest tablets

• Clinorette tablets

• Climesse tablets

• Elleste duet Conti tablets

• Elleste duet tablets

• Evorel sequi patches

• Evorel continuous  patches

• Kliofem tablets

• Nuvelle continuous tables

• Nofem tablets

• Trisequens tablets

Furthermore, Kliovance can possibly reduce the effectiveness of drugs used to reduce high blood pressure. At the same time, it may oppose the effect of fluid-losing diuretic medicines. It can also lower antiepileptic medicine lamotrigine levels in the blood.

 Administration and Dosage

As a continuous combined form of HRT, Kliovance is designed for women with intact uteruses. Therefore, one tablet needs to be taken orally and once per day at the same time,  without interruption. 

For the initiation and continuation of postmenopausal symptoms treatment, the patient is advised to use the lowest but effective dose. The dose should be administered in the shortest duration provided that the benefits outweigh the risks.

The patient is advised to use this medicine as instructed by the pharmacist or doctor if she is not unsure. Once she is done with the tablets (28 of them) in the pack, the patient can proceed with the new pack without interruption in between. 

For more information on how to take Kliovance tablets, the patient can check the ‘User Instructions ‘ printed at the bottom of the package leaflet.

If the patient takes more Kliovance than it is prescribed, she should inform the doctor or pharmacist as soon as possible. An overdose of any HRTdrug can cause some sickness or vomiting.  

If by any chance the patient forgets to take her tablets, she can do so within the following 12 hours without missing. If it is more than 12 hours she can just skip that particular dose and start all over again the next day. She should never take a double dose in the hope of making up for the forgotten dose. Forgetting to take the dose as prescribed can increase the incidence of breakthrough bleeding or spotting if the patient still has her womb. 

If the patient wishes to stop taking Kliovance, she should discuss it with her doctor to learn more about the effects of stopping the treatment and other possibilities. 

If the patient is about to undergo a surgical operation, she should inform the surgeon that she has been taking Kliovance.In this sense, she must stop taking these tablets about two to six weeks prior to the operation to minimize cases of blood clotting (thrombosis).

Storage

Kliovance should be stored away from children. Also, this medicine should not be used after its expiry date which is usually well-stated on the label or outer carton. It should not be stored above 25? or placed in a refrigerator. Most importantly, Kliovance should be kept away from light.

Final Thought

Kliovance is an effective medicine that delivers hormonal replacement therapy to women who experience distressing symptoms in their menopause. Visitors can learn more about Kliovance from Kiwi, the online doctor server. Also, visitors can buy this drug subject to online doctor’s approval whereby orders are shipped to most countries.