Manufactuered by Pfizer, shipped from India with tracking.

Premarin Cream contains conjugated estrogens, a mix of estrogen hormones. It is predominantly used in menopausal women who are experiencing vaginal symptoms of menopause---such as dryness or irritation---when other menopausal symptoms are not present, or not severe enough to warrant treatment.

Note that Premarin Cream does not contain a progestin; it is an estrogen-only medication. Women taking estrogen therapy who have an intact uterus, regardless of menopause, are nearly always advised to also take a progestin to mitigate risk of uterine cancer. Women who have had their uterus removed do not need to worry about progestins.

Progestins and estrogens are often combined into a single treatment, though this is uncommon with vaginal creams. Women utilizing creams may need to buy progestin-only medications, which can be browsed here. Dosage should be determined by a doctor, as it will depend on a number of personal variables.

Using Premarin Cream

Premarin Cream is applied directly to the vagina to ease or eliminate relatively common symptoms of menopause, including:

• Dryness
• Burning
• Irritation
• Painful intercourse

The cream is very effective at treating the above, more so than administration of estrogen by tablet, since it is applied directly to the surface that needs it most. While it may alleviate other symptoms of menopause---hot flashes, night sweats, and so forth---to some small degree, it will not be nearly as effective as tablets.

Premarin Cream comes with an applicator to make intravaginal administration easy. The applicator contains dosing measurements. Detailed instructions for use come with each package.

Dosing usually starts low, gradually increased if needed. There are two standard treatment methods:

• Administer the cream once per day for 21 days, then take a week off before resuming treatment; or
• Administer the cream twice per week, such as Sunday and Wednesday.

Which method is used is best determined by a doctor; it will depend on what exactly is being treated and its severity.

Duration of treatment will likewise vary; hormone replacement therapy is not meant to be indefinite. Most women, given time, will adjust to menopause and no longer experience symptoms even without estrogen therapy. Vaginal symptoms, however, tend to be the most persistant. The need for continued estrogen therapy should be reevaluated every 3 to 6 months, simply by stopping use of Premarin Cream and seeing if symptoms return.

Potential Complications

Certain patients are poor candidates for Premarin Cream and shouldn't use this product, namely those who:

• Are or may be pregnant
• Have or develop undiagnosed vaginal bleeding
• Have a history, including family history, of estrogen-dependent breast or uterine cancer
• Have liver disease
• Have a history of blood clots or cardiovascular disease

Doctors and dentists should be informed prior to surgery that the medication is being taken.

Though rare, Premarin Cream can cause potentially serious side effects. Seek medical attention if experiencing:

• Moderate to severe abdominal pain
• Vaginal bleeding
• Symptoms of a blood clot---swelling and redness in the legs, sudden severe chest pain, sudden vision loss
• Memory problems
• Confusion

Other medications are fairly unlikely to interfere with Premarin Cream, but it can happen. To be on the safe side, always double-check with a doctor or pharmacist before mixing treatments, especially other vaginally-administered medications.